REBLOZYL should be reconstituted and administered by a healthcare professional¹

Step 1: Add Sterile Water for Injection, USP

Reconstitute with Sterile Water for Injection, USP using volumes described in the Reconstitution Volumes table above with the stream directed onto the lyophilized powder. Allow to stand for 1 minute.

Step 2: Discard the needle and syringe used for reconstitution

The needle and syringe used for reconstitution should not be used for SC injections.

Step 3: Mix and wait

Gently swirl the vial in a circular motion for 30 seconds. Stop swirling and let the vial sit in an upright position for 30 seconds.

Step 4: Inspect the solution

Inspect the solution for undissolved particles. If undissolved powder is observed, repeat step 3 until the powder is completely dissolved.

Step 5: Mix and wait

Invert the vial and gently swirl in an inverted position for 30 seconds. Bring the vial back to the upright position, and let it sit for 30 seconds.

Step 6: Ensure reconstitution

Repeat step 5 seven more times to ensure complete reconstitution of material on the sides of the vial.

Step 7: Inspect

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration whenever solution and container permit. REBLOZYL is a colorless to slightly yellow, clear to slightly opalescent solution, which is free of foreign particulate matter. Do not use if undissolved product or foreign particulate matter is observed.